Grade-dependent Response to Finasteride in Early Prostate Cancer
نویسندگان
چکیده
a Veterans Affairs Medical Center, 1201 N.W. 16th Street, Miami, FL 33125, USA b Department of Urology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th St, Miami, FL 33199, USA c Divisions of Hematology/Oncology and Endocrinology, Department of Medicine, University of Miami, Miller School of Medicine, 1800 N.W. 10th Ave, Miami, FL 33126, USA d Department of Pathology, University of Miami, Miller School of Medicine, 1800 N.W. 10th Ave, Miami, FL 33125, USA e Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, 1800 N.W. 10th Ave, Miami, FL 33125, USA
منابع مشابه
Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer☆
BACKGROUND In the Prostate Cancer Prevention Trial, finasteride selectively suppressed low-grade prostate cancer and significantly reduced the incidence of prostate cancer in men treated with finasteride compared with placebo. However, an apparent increase in high-grade disease was also observed among men randomized to finasteride. We aimed to determine why and hypothesized that there is a grad...
متن کاملFinasteride does not increase the risk of high-grade prostate cancer: a bias-adjusted modeling approach.
Finasteride taken for 7 years in the Prostate Cancer Prevention Trial (PCPT) reduced the risk of prostate cancer by 25%, but with an apparent increased risk of high-grade disease. Subsequent analyses found that finasteride biases toward improved prostate cancer detection and accuracy in prostate cancer grading at biopsy. In our first analysis of the present study, we accounted for these biases ...
متن کاملCancer Prevention Research Finasteride Does Not Increase the Risk of High-Grade Prostate Cancer: A Bias-Adjusted Modeling Approach
Finasteride taken for 7 years in the Prostate Cancer Prevention Trial (PCPT) reduced the risk of prostate cancer by 25%, but with an apparent increased risk of high-grade disease. Subsequent analyses found that finasteride biases toward improved prostate cancer detection and accuracy in prostate cancer grading at biopsy. In our first analysis of the present study, we accounted for these biases ...
متن کاملFinasteride Concentrations and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial
OBJECTIVE In the Prostate Cancer Prevention Trial (PCPT), finasteride reduced the risk of prostate cancer by 25%, even though high-grade prostate cancer was more common in the finasteride group. However, it remains to be determined whether finasteride concentrations may affect prostate cancer risk. In this study, we examined the association between serum finasteride concentrations and the risk ...
متن کاملEffect of finasteride on the sensitivity of PSA for detecting prostate cancer.
BACKGROUND In the Prostate Cancer Prevention Trial (PCPT), men receiving finasteride had a 24.8% lower risk of prostate cancer than men receiving placebo but a higher risk of high-grade cancer. We examined the impact of finasteride on the sensitivity and area under the receiver operating characteristic curve (AUC) of prostate-specific antigen (PSA) for detecting prostate cancer. METHODS We st...
متن کامل